Harlequin American
Uncategorized July 23rd. 2008, 5:53pmHarlequin American
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Accutane: A Brief Discussion
Isotretinoin is a medication that has been used in the treatment of cancers and severe skin conditions. Its popular name in the US is accutane prior to July 2009. For acne treatments, when all other options have failed, it is used as the "last resort". Apart from its main use as a chemotherapy medication, it has also been tested as a treatment for harlequin-type itchyosis. This is a sort of skin deformation that causes patients to develop plate-like skin, resembling those of scales, and causes death shortly after birth.
The drug is a non-selective medication. It means that its effects affects both healthy and malign cells. Therefore, administration and dosage should be under strict scrutiny. Because of its ability to kill rapidly dividing cells and slow down the growth of tumors, it became widely used for cancer treatments. It is a retinoid. It is naturally found in the human body in small quantities. However, its quantity within the human body is not enough to generate the effects needed for treatment. In the US, accutane has been placed under strict government regulation, along with pharmaceutical industry restrictions, making it hard to obtain. The reason for this is the drug's detrimental ability to cause birth defects.
Accutane is a known teratogen, a substance able to cause birth defects when taken during pregnancy. As a result, pregnant and breastfeeding women are strongly advised not to use the medication. Visual and hearing impairment, deformed earlobes, and mental retardation are few of the most common defects suffered because of this. Between 1982 and 2003, an estimated 2,000 American women took the drug while they are pregnant. 160 infants were born with defects. In 2005, Food and Drug Administration set programs and regulations that make sure that female patients do not receive the drug during pregnancy. Despite the lack of data that it can be excreted through seminal fluid, the programs were extended to male patients as well.
Dryness of the skin, possible infection of the cuticles, rashes, hyperlipidaemia and back pains are other known side effects of this drug. Rarer side effects are known to be cataracts, disturbances in menstrual flow, pancreatitis, hepatitis, psychosis and depression. According to a Mexican study, male patients taking the drug also have the risk of experiencing erectile dysfunction. . Hair loss, a decrease in night vision, degenerative disc disease and acne rosacea have been known to manifest as side effects of this drug, even after treatment has been discontinued.
To date, the mechanism action for this medication is still unknown. Signs that it amplifies the production of neutrophil-gelatinase-associated lipocalin in the skin - a substance believed to cause apoptosis in sebaceous gland cells, have been shown in recent studies. Apoptosis is the term for cellular death due to internal factors. It means accutane has the ability to stunt the normal production of sebum. The effect it has on sebum production is said to be temporary. However, reports indicate that the remission of any condition that has been treated with Accutane is "complete and prolonged."
Across the US, purchase of the drug requires a physician's prescription, making the drug hard to acquire. In fact, the FDA iPLEDGE program regulates the number of medical professionals who can prescribe the drug. However, since the patent on the drug lapsed in 2002, isotretinoin has become more available over the Internet. While private importation of the drug is currently legal, its use could constitute a violation of existing statues.
About the Author
Due to the various risks involved, it is not unusual to hear about an accutane lawsuit once in a while. Despite FDA regulations, there are still those who prescribe the medication without having the authority to do so.
Assassin's Creed Brotherhood : The ALL-AMERICAN- AMERICAN HArleQuiN


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